Notes on Building Serious Things
Taste, institutions, incentives, and why most projects fail early
A meditation on taste, institutions, incentives, and why most projects fail before they become technically difficult.
Writing
Unfinished thoughts on science, systems, and the gap between what we measure and what we mean.
5 pieces · 6 categories
Taste, institutions, incentives, and why most projects fail early
A meditation on taste, institutions, incentives, and why most projects fail before they become technically difficult.
On explanation, optimism, fallibilism, and intellectual progress
A review of explanation, optimism, fallibilism, and what it means to make intellectual progress.
Teaching uncertainty, taste, judgment, and standards
Research education is not just about teaching methods. It is about teaching uncertainty, taste, judgment, and standards.
Between scientific truth, clinical usefulness, and economic reality
The hardest part of biotech strategy is often translating between scientific truth, clinical usefulness, operational feasibility, and economic reality.